Shape beef into patties, about 4 ounces each. Sprinkle each side with Cajun seasoning.
Cook over medium-high heat about 6 minutes per side or until instant-read thermometer registers 160°F.
Meanwhile, in small bowl stir together mayonnaise, blue cheese and mustard. Serve burgers, topped with blue cheese sauce, lettuce, tomato and onion, on toasted buns.
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